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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4G1
All Species:
8.48
Human Site:
S450
Identified Species:
26.67
UniProt:
Q04637
Number Species:
7
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04637
NP_937884.1
1599
175491
S450
A
T
A
P
S
A
T
S
P
A
Q
E
E
E
M
Chimpanzee
Pan troglodytes
XP_001146472
1599
175483
C450
A
T
A
P
S
A
T
C
P
A
Q
E
E
E
M
Rhesus Macaque
Macaca mulatta
XP_001093301
1504
163783
D456
N
G
M
V
P
S
E
D
L
E
P
E
V
E
S
Dog
Lupus familis
XP_535377
1722
190693
T581
A
A
A
T
N
I
G
T
A
G
V
P
T
T
V
Cat
Felis silvestris
Mouse
Mus musculus
Q6NZJ6
1600
176058
T459
P
P
V
A
P
S
D
T
S
P
A
Q
E
E
E
Rat
Rattus norvegicus
XP_001060756
1592
175069
T452
P
P
V
A
P
S
D
T
S
A
A
Q
E
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423296
1788
196302
S638
S
T
A
P
S
P
P
S
P
L
P
P
S
A
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001073669
1585
176395
T467
V
K
A
S
V
E
E
T
E
K
E
K
A
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
87.2
46.8
N.A.
91.3
91
N.A.
N.A.
44.9
N.A.
58.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
87.4
59.2
N.A.
94.1
93.8
N.A.
N.A.
58.1
N.A.
71.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
13.3
13.3
N.A.
13.3
20
N.A.
N.A.
40
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
20
33.3
N.A.
33.3
40
N.A.
N.A.
46.6
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
38
13
63
25
0
25
0
0
13
38
25
0
13
13
0
% A
% Cys:
0
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
25
13
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
13
25
0
13
13
13
38
50
75
38
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
13
0
0
0
0
13
0
0
13
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
13
0
0
0
0
0
0
0
13
0
13
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
13
13
0
0
0
0
0
% L
% Met:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
25
% M
% Asn:
13
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
25
25
0
38
38
13
13
0
38
13
25
25
0
0
13
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
25
25
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
13
0
0
13
38
38
0
25
25
0
0
0
13
0
13
% S
% Thr:
0
38
0
13
0
0
25
50
0
0
0
0
13
13
0
% T
% Val:
13
0
25
13
13
0
0
0
0
0
13
0
13
0
13
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _